Regulation of systemic arterial blood pressure by hormone

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by hormone pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL33, DDOST, and ROGDI, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by hormone activity versus MRPL33 in BLOOD_Leukemia (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MRPL33 →	+1.239	+0.727	<.001	.008	3	4
BLOOD_Leukemia	DDOST →	+0.772	+0.567	<.001	.002	3	4
BLOOD_Leukemia	ROGDI →	+1.273	+0.515	<.001	.008	3	4
BLOOD_Leukemia	FNDC3B →	+1.213	+0.473	.002	.008	3	4
STOMACH	ARHGEF17 →	+2.505	+0.334	.002	.006	3	4
BLOOD_Leukemia	GPR63 →	-0.961	-0.504	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001990 vs MRPL33 — BLOOD_Leukemia

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