Nervous system process involved in regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Nervous system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VAT1, PELP1_S481, and FNBP4_S508, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nervous system process involved in regulation of systemic arterial blood pressure activity versus VAT1 in LSCC (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VAT1 →	+0.197	+0.082	.002	<.001	3	5
LSCC	PELP1_S481 →	-0.406	-0.083	<.001	<.001	3	4
LSCC	FNBP4_S508 →	-0.392	-0.083	.001	<.001	3	4
PDAC	CD8A →	-0.615	-0.104	<.001	<.001	3	4
LSCC	MT1E →	+1.193	+0.136	.001	<.001	3	4
GBM	TK2 →	+0.272	+0.083	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001976 vs VAT1 — LSCC

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