Nervous system process involved in regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Nervous system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA5, MYLK, and SLX1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA5 grouped by Nervous system process involved in regulation of systemic arterial blood pressure-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITGA5 →	-1.700	-0.896	.001	.002	3	6
CNS	MYLK →	-1.804	-0.944	.008	.001	3	4
BREAST	SLX1A →	+1.125	+0.721	.001	.004	3	4
BREAST	TMC6 →	+1.182	+0.529	.008	.004	3	4
SOFT_TISSUE	RPL34 →	+0.801	+1.562	.005	.002	3	4
CNS	SRGN →	-2.934	-0.982	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA5 by Nervous system process involved in regulation of systemic arterial blood pressure activity — BLOOD_Leukemia

Explore this box plot interactively →