Nervous system process involved in regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Nervous system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PFI-3, I-BET-762, and DMOG, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFI-3 grouped by Nervous system process involved in regulation of systemic arterial blood pressure-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PFI-3 →	+0.273	+0.669	.042	.002	2	1
BONE	I-BET-762 →	+0.798	+0.669	.031	.002	2	1
BONE	DMOG →	+0.680	+0.669	.024	.002	2	1
BONE	Oxaliplatin →	-0.675	-0.720	.026	.001	2	1
BONE	Carmustine →	-0.859	-0.720	.001	.001	2	1
BONE	AGI-5198 →	-0.490	-0.720	.020	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFI-3 by Nervous system process involved in regulation of systemic arterial blood pressure activity — BONE

Explore this box plot interactively →