Response to amphetamine

Across TCGA patient cohorts, RNA activity of the Response to amphetamine pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRRM2_S783, SUN2_S12, and DLG5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amphetamine activity versus SRRM2_S783 in HNSC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRRM2_S783 →	-0.585	-0.095	<.001	<.001	3	6
UCEC	SUN2_S12 →	+0.662	+0.063	<.001	<.001	3	6
UCEC	DLG5 →	+0.308	+0.069	.001	.002	3	6
GBM	PBXIP1_S43 →	+0.617	+0.043	<.001	.002	3	6
CCRCC	PRPF38B_S529 →	-0.644	-0.056	.001	.004	3	6
CCRCC	SRRM2_S1424 →	-0.730	-0.082	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001975 vs SRRM2_S783 — HNSC

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