Response to amphetamine

Across TCGA patient cohorts, RNA activity of the Response to amphetamine pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIGLEC18P, CHL1, and LIG3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amphetamine activity versus SIGLEC18P in PDAC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SIGLEC18P →	-0.252	-0.444	<.001	<.001	3	5
LSCC	CHL1 →	-1.103	-0.803	<.001	<.001	3	4
LUAD	LIG3 →	+0.340	+0.564	.001	.007	3	4
COAD	RALB →	-0.327	-0.586	.001	.001	3	4
BRCA	LRRC15 →	-1.382	-0.563	<.001	.001	3	4
BRCA	MAF →	-0.495	-0.445	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001975 vs SIGLEC18P — PDAC

Explore this scatter interactively →