Response to amphetamine

Across TCGA patient cohorts, RNA activity of the Response to amphetamine pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B2, SNRNP40, and SPECC1_T78, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amphetamine activity versus SF3B2 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SF3B2 →	+0.134	+0.478	<.001	<.001	3	4
BRCA	SNRNP40 →	+0.148	+0.563	<.001	<.001	3	3
BRCA	SPECC1_T78 →	-0.563	-1.059	<.001	<.001	3	3
GBM	STK10_S438 →	-0.606	-0.541	<.001	<.001	3	3
BRCA	ZNF318_S2101 →	+0.518	+0.510	<.001	<.001	3	3
BRCA	CDC5L →	+0.153	+0.514	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001975 vs SF3B2 — BRCA

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