Response to amphetamine

Across TCGA cell cohorts, RNA activity of the Response to amphetamine pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHIC2, CHD1L, and DDHD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amphetamine activity versus CHIC2 in URINARY_TRACT (Pearson r = -0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CHIC2 →	-1.100	-1.766	<.001	<.001	3	4
PANCREAS	CHD1L →	+0.743	+0.844	.003	.008	3	4
BLOOD_Leukemia	DDHD2 →	+1.398	+0.818	<.001	.001	3	3
SOFT_TISSUE	CXCL8 →	-6.547	-0.285	.004	.002	2	4
SOFT_TISSUE	SLC5A3 →	+2.615	+0.244	.001	.003	3	3
SOFT_TISSUE	STK19 →	-0.682	-0.255	.009	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001975 vs CHIC2 — URINARY_TRACT

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