Blood vessel remodeling

Across TCGA patient cohorts, RNA activity of the Blood vessel remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, RSU1, and VIM_S22, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel remodeling activity versus PRKG1 in UCEC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+0.937	+0.070	<.001	<.001	3	9
BRCA	RSU1 →	+0.365	+0.025	<.001	<.001	3	8
OV	VIM_S22 →	+0.775	+0.040	.002	<.001	3	8
LSCC	CACYBP →	-0.348	-0.037	<.001	<.001	3	8
UCEC	TLN1 →	+0.445	+0.051	<.001	.003	3	8
UCEC	TNS1 →	+0.605	+0.061	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001974 vs PRKG1 — UCEC

Explore this scatter interactively →