Blood vessel remodeling

Across TCGA patient cohorts, RNA activity of the Blood vessel remodeling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, MYLK, and MYL9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel remodeling activity versus CNN1 in OV (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNN1 →	+1.728	+0.913	<.001	<.001	3	9
COAD	MYLK →	+1.017	+0.455	.002	.001	3	9
BRCA	MYL9 →	+0.941	+0.554	<.001	.007	3	8
OV	AOC3 →	+1.630	+0.685	<.001	<.001	3	8
OV	VGLL3 →	+1.150	+0.674	<.001	.003	3	8
OV	ACTA2 →	+1.714	+0.626	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001974 vs CNN1 — OV

Explore this scatter interactively →