Blood vessel remodeling

Across TCGA cell cohorts, RNA activity of the Blood vessel remodeling pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLOC1S1, ABCB6, and ARID5B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BLOC1S1 grouped by Blood vessel remodeling-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	BLOC1S1 →	-0.939	-1.273	<.001	<.001	3	4
BLOOD_Lymphoma	ABCB6 →	+1.563	+1.658	.004	<.001	3	4
KIDNEY	ARID5B →	+1.381	+1.219	.005	.004	2	5
BLOOD_Leukemia	EID2 →	+0.655	+1.141	.001	<.001	3	4
SKIN	ELK1 →	+0.661	+0.763	<.001	.006	3	3
PANCREAS	SYNGR1 →	+1.318	+0.848	.005	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BLOC1S1 by Blood vessel remodeling activity — PANCREAS

Explore this box plot interactively →