Suckling behavior

pathway activity — cross-omics
GO:0001967Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Suckling behavior pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TXNDC17, USP43_S818, and CLPB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCTXNDC17 →+0.339+0.061.004.00735
HNSCUSP43_S818 →+0.590+0.049.009.00335
GBMCLPB →+0.177+0.074<.001<.00134
COADSPARCL1_S92 →-0.720-0.048<.001.00134
COADSYNM →-0.778-0.055<.001<.00134
COADCAVIN2_S203 →-0.394-0.055.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration