"Synaptic transmission, dopaminergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, dopaminergic" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPC1, MTA1, and WDR44_S50, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, dopaminergic" activity versus GPC1 in LSCC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPC1 →	-0.504	-0.055	<.001	<.001	3	7
GBM	MTA1 →	-0.301	-0.092	<.001	<.001	3	6
LUAD	WDR44_S50 →	+0.236	+0.066	.002	<.001	3	6
BRCA	SGCD →	-0.404	-0.071	<.001	<.001	3	5
COAD	UBA2 →	-0.275	-0.061	.001	<.001	2	6
GBM	CASP4 →	+0.493	+0.063	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001963 vs GPC1 — LSCC

Explore this scatter interactively →