"Synaptic transmission, dopaminergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, dopaminergic" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ODF2, RUSC1, and PPIAP22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, dopaminergic" activity versus ODF2 in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ODF2 →	+0.663	+0.213	.004	<.001	3	4
LUAD	RUSC1 →	+0.516	+0.162	<.001	.003	3	4
CCRCC	PPIAP22 →	+0.296	+0.087	.005	.005	3	3
OV	DPRXP6 →	+0.165	+0.175	<.001	<.001	3	3
UCEC	NUBPL →	-0.369	-0.131	.009	.005	3	3
COAD	H3C15 →	+0.019	+0.145	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001963 vs ODF2 — HNSC

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