Positive regulation of neurotransmitter secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurotransmitter secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, SEC61B, and SYN1_S67, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter secretion activity versus STXBP1 in GBM (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP1 →	+0.983	+0.127	<.001	<.001	3	5
GBM	SEC61B →	-0.303	-0.090	.001	<.001	3	5
GBM	SYN1_S67 →	+1.292	+0.109	<.001	<.001	3	4
BRCA	CPE →	+0.794	+0.034	.001	.001	3	4
GBM	DLG4_S295 →	+1.000	+0.116	<.001	<.001	3	4
GBM	FNDC3B →	-0.406	-0.070	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001956 vs STXBP1 — GBM

Explore this scatter interactively →