Positive regulation of neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX1A, BGLAP, and PAQR9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STX1A grouped by Positive regulation of neurotransmitter secretion-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	STX1A →	-0.518	-1.609	<.001	<.001	3	9
LARGE_INTESTINE	BGLAP →	-0.206	-1.125	<.001	<.001	3	6
LUNG_NSCLC_LUAD	PAQR9 →	-0.072	-0.970	.002	<.001	3	5
BONE	PCDHA11 →	-0.272	-1.882	.009	<.001	3	4
LUNG_SCLC	DLX2 →	-0.275	-0.940	<.001	.004	2	5
LUNG_SCLC	ARHGAP27 →	-0.312	-0.956	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STX1A by Positive regulation of neurotransmitter secretion activity — OVARY

Explore this box plot interactively →