Positive regulation of neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L2, SMCHD1, and OCIAD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAD2L2 grouped by Positive regulation of neurotransmitter secretion-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAD2L2 →	+1.014	+1.233	.009	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SMCHD1 →	+1.124	+1.248	.003	<.001	3	5
BLOOD_Leukemia	OCIAD2 →	-3.218	-1.290	<.001	.001	3	5
LIVER	ZNF689 →	+0.973	+1.749	<.001	<.001	3	4
LUNG_SCLC	ZGLP1 →	+1.158	+1.031	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MPDU1 →	+0.607	+0.789	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAD2L2 by Positive regulation of neurotransmitter secretion activity — STOMACH

Explore this box plot interactively →