Positive regulation of neurotransmitter secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurotransmitter secretion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED7, BMP8B, and BIRC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurotransmitter secretion activity versus TMED7 in OVARY (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMED7 →	-0.611	-0.958	.007	.005	3	4
LARGE_INTESTINE	BMP8B →	-1.297	-1.282	.002	<.001	2	5
SKIN	BIRC3 →	-2.275	-1.047	.002	.007	3	4
CNS	MTMR4 →	-0.688	-1.001	.002	.006	3	4
URINARY_TRACT	PLCG1 →	+1.167	+1.925	.001	<.001	3	3
URINARY_TRACT	SEMA4F →	+0.962	+1.906	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001956 vs TMED7 — OVARY

Explore this scatter interactively →