Negative regulation of cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SULT1A1, CORO1C, and ETS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cell-matrix adhesion activity versus SULT1A1 in OVARY (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SULT1A1 →	-1.752	-1.042	.008	<.001	3	6
LUNG_NSCLC_LUAD	CORO1C →	+1.237	+1.134	<.001	<.001	3	5
BLOOD_Lymphoma	ETS1 →	+1.453	+0.602	.004	.006	3	4
LUNG_SCLC	GNAL →	-1.601	-0.581	<.001	.003	3	4
OVARY	HMGA1 →	+1.822	+1.133	.001	.001	3	4
OVARY	IGFBP2 →	-4.193	-1.278	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001953 vs SULT1A1 — OVARY

Explore this scatter interactively →