Regulation of cell-matrix adhesion

Across TCGA patient cohorts, RNA activity of the Regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD9-IT1, MYL9, and KLHL4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-matrix adhesion activity versus SMAD9-IT1 in BRCA (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMAD9-IT1 →	+0.524	+0.229	.009	.008	3	3
BRCA	MYL9 →	+1.420	+0.250	<.001	<.001	3	2
BRCA	KLHL4 →	+0.371	+0.239	<.001	.002	3	2
BRCA	SRPX2 →	+1.205	+0.214	<.001	.004	3	2
BRCA	ZNF423 →	+1.037	+0.207	<.001	.005	3	2
BRCA	CRISPLD2 →	+1.488	+0.232	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001952 vs SMAD9-IT1 — BRCA

Explore this scatter interactively →