Regulation of cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL6, KLHDC7A, and MYBBP1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NOL6 grouped by Regulation of cell-matrix adhesion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NOL6 →	-0.971	-0.305	.003	.007	2	5
BONE	KLHDC7A →	+0.508	+1.118	.005	.002	3	3
PANCREAS	MYBBP1A →	-1.226	-0.237	.002	.002	3	3
PANCREAS	MFSD4A →	+0.702	+0.183	.006	.002	3	3
PANCREAS	INKA1 →	-1.149	-0.185	.002	.001	3	3
BLOOD_Myeloma	ELL2 →	+1.881	+1.509	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NOL6 by Regulation of cell-matrix adhesion activity — LIVER

Explore this box plot interactively →