Regulation of cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-matrix adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, TEAD1, and PPP1CB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Regulation of cell-matrix adhesion-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAX →	-0.597	-0.218	.005	.009	3	7
LIVER	TEAD1 →	+0.535	+0.063	.004	.005	3	7
URINARY_TRACT	PPP1CB →	+0.550	+0.088	.001	.004	3	6
LARGE_INTESTINE	TLN1 →	+0.365	+0.080	.002	<.001	3	6
CNS	TRAPPC3 →	-0.360	-0.118	<.001	<.001	3	6
URINARY_TRACT	PPP1R12A →	+0.533	+0.064	<.001	.004	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Regulation of cell-matrix adhesion activity — BONE

Explore this box plot interactively →