Regulation of cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Regulation of cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLX4, RAP1GDS1, and WDR41, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell-matrix adhesion activity versus DLX4 in BONE (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DLX4 →	-3.460	-0.169	<.001	.001	3	6
KIDNEY	RAP1GDS1 →	+0.743	+0.250	.001	.005	3	5
SKIN	WDR41 →	+0.698	+0.231	<.001	.003	3	5
OVARY	FRAT2 →	-1.297	-0.215	.001	<.001	2	6
URINARY_TRACT	TNK1 →	-0.891	-0.411	.001	<.001	3	4
OVARY	STX2 →	+1.782	+0.227	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001952 vs DLX4 — BONE

Explore this scatter interactively →