Lymphangiogenesis

Across TCGA patient cohorts, RNA activity of the Lymphangiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSMD2, RUBCNL, and PROX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphangiogenesis activity versus CSMD2 in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSMD2 →	+0.742	+0.278	<.001	<.001	3	5
GBM	RUBCNL →	+0.812	+0.706	.001	<.001	3	5
GBM	PROX1 →	+1.276	+0.552	<.001	<.001	3	5
LSCC	ACTA2 →	+0.779	+0.191	<.001	<.001	3	5
BRCA	PRRX1 →	+1.029	+0.314	.001	.004	3	5
BRCA	TNFAIP6 →	+0.904	+0.332	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001946 vs CSMD2 — LSCC

Explore this scatter interactively →