Lymphangiogenesis

Across TCGA cell cohorts, RNA activity of the Lymphangiogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCERG1, SAPCD2, and UBL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCERG1 grouped by Lymphangiogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCERG1 →	-0.231	-1.198	.004	.001	3	5
BREAST	SAPCD2 →	+0.160	+1.162	.007	<.001	3	4
BREAST	UBL5 →	-0.360	-0.866	.006	.003	3	4
BREAST	RBM14-RBM4 →	+0.206	+0.980	.003	.003	3	4
LARGE_INTESTINE	RFWD3 →	+0.188	+1.021	.007	.003	3	4
LARGE_INTESTINE	NME1 →	+0.159	+0.856	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCERG1 by Lymphangiogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →