Positive regulation of endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN4, SPARC, and CNRIP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell proliferation activity versus CCN4 in OV (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCN4 →	+1.202	+0.565	.002	.002	3	7
OV	SPARC →	+1.423	+0.581	<.001	.002	3	7
BRCA	CNRIP1 →	+0.890	+0.413	<.001	<.001	3	7
BRCA	ZEB1 →	+1.137	+0.424	<.001	<.001	3	7
UCEC	PDLIM3 →	+1.930	+0.302	<.001	<.001	3	7
UCEC	JCAD →	+0.848	+0.325	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001938 vs CCN4 — OV

Explore this scatter interactively →