Positive regulation of endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFA, RAC2, and LAMA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGFA grouped by Positive regulation of endothelial cell proliferation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TGFA →	-2.994	-0.311	<.001	<.001	3	6
LUNG_NSCLC_LUAD	RAC2 →	-2.099	-0.391	.002	.002	3	4
BREAST	LAMA3 →	-2.328	-0.235	<.001	<.001	2	5
PANCREAS	PDGFRL →	+1.114	+1.041	.002	.004	3	4
PANCREAS	ASIC1 →	+0.917	+1.019	.001	.003	3	4
STOMACH	TBKBP1 →	+2.031	+0.237	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGFA by Positive regulation of endothelial cell proliferation activity — STOMACH

Explore this box plot interactively →