Positive regulation of endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRP1, KRT18, and SCAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell proliferation activity versus ESRP1 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ESRP1 →	+3.353	+0.250	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	KRT18 →	+1.825	+0.257	.003	.005	3	4
SKIN	SCAP →	-0.767	-0.221	.004	.007	3	4
LUNG_SCLC	PRSS27 →	+1.170	+0.241	<.001	<.001	3	4
LUNG_SCLC	B3GNT5 →	+2.606	+0.263	<.001	<.001	3	4
LUNG_SCLC	MFSD12 →	+0.926	+0.297	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001938 vs ESRP1 — LUNG_SCLC

Explore this scatter interactively →