Negative regulation of endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of endothelial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM33_S862, BGN, and TBC1D2B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endothelial cell proliferation activity versus TRIM33_S862 in GBM (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM33_S862 →	-0.548	-0.047	.001	<.001	3	9
BRCA	BGN →	+0.854	+0.034	<.001	<.001	3	9
UCEC	TBC1D2B →	+0.347	+0.075	<.001	<.001	3	8
OV	CSE1L →	-0.357	-0.049	<.001	<.001	3	8
GBM	DAB2 →	+0.701	+0.049	<.001	<.001	3	8
BRCA	DCN →	+1.006	+0.035	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001937 vs TRIM33_S862 — GBM

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