Negative regulation of endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYH10, WDR13, and MITD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYH10 grouped by Negative regulation of endothelial cell proliferation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYH10 →	+2.448	+1.000	.002	<.001	3	4
BLOOD_Leukemia	WDR13 →	+0.609	+0.947	.002	.001	3	4
CNS	MITD1 →	+0.566	+1.314	<.001	<.001	3	4
BLOOD_Myeloma	ZNF711 →	+2.656	+1.309	.004	.005	3	3
BLOOD_Myeloma	PTPDC1 →	+1.657	+1.721	<.001	<.001	3	3
LIVER	MAP7D1 →	+1.822	+1.335	.002	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYH10 by Negative regulation of endothelial cell proliferation activity — BLOOD_Leukemia

Explore this box plot interactively →