Negative regulation of endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD37, CMC2, and SRPK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endothelial cell proliferation activity versus ANKRD37 in LUNG_SCLC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANKRD37 →	+0.836	+0.207	.005	<.001	3	6
OVARY	CMC2 →	+0.888	+0.267	<.001	.003	3	5
BLOOD_Lymphoma	SRPK2 →	+1.420	+0.215	.003	.001	3	4
SKIN	STK19 →	+0.722	+0.223	.007	.006	3	4
BLOOD_Leukemia	C4A →	+0.625	+0.169	.005	.003	3	4
LUNG_SCLC	MARCHF9 →	+0.749	+0.183	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001937 vs ANKRD37 — LUNG_SCLC

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