Endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRB, NID1, and MYCT1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell proliferation activity versus PDGFRB in UCS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	PDGFRB →	+2.381	+0.050	<.001	<.001	3	33
TGCT	NID1 →	+2.303	+0.048	<.001	<.001	3	33
TGCT	MYCT1 →	+1.697	+0.048	<.001	<.001	3	33
TGCT	CD93 →	+1.813	+0.051	<.001	<.001	3	33
MESO	DIPK2B →	+1.351	+0.037	<.001	<.001	3	33
TGCT	ROBO4 →	+1.409	+0.047	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001935 vs PDGFRB — UCS

Explore this scatter interactively →