Endothelial cell proliferation

Across TCGA patient cohorts, RNA activity of the Endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM3, ZEB2, and TIMP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell proliferation activity versus PDLIM3 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDLIM3 →	+1.539	+0.248	<.001	<.001	3	9
UCEC	ZEB2 →	+1.047	+0.309	<.001	.002	3	9
UCEC	TIMP3 →	+2.205	+0.495	<.001	.007	3	8
OV	CCN4 →	+1.222	+0.169	<.001	<.001	3	8
UCEC	PMP22 →	+1.174	+0.455	<.001	.005	3	8
CCRCC	PDE1A →	+1.016	+0.328	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001935 vs PDLIM3 — OV

Explore this scatter interactively →