Endothelial cell proliferation

Across TCGA cell cohorts, RNA activity of the Endothelial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5R3, RPL6, and APOBEC3C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB5R3 grouped by Endothelial cell proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CYB5R3 →	-1.176	-1.439	<.001	<.001	3	5
OVARY	RPL6 →	+0.589	+1.137	.004	<.001	3	4
LUNG_NSCLC_LUSC	APOBEC3C →	-1.825	-1.159	.004	<.001	3	4
PANCREAS	EPS8L2 →	-1.122	-1.068	.008	.001	3	4
SOFT_TISSUE	PDLIM1 →	-2.533	-1.002	.009	.001	1	6
LUNG_NSCLC_LUSC	TRIM21 →	-1.006	-1.247	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB5R3 by Endothelial cell proliferation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →