B-1 B cell differentiation

pathway activity — cross-omics
GO:0001923Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the B-1 B cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASAL3_S51, SPTBN1_S2165, and NES_S1286, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADRASAL3_S51 →+0.635+0.201<.001<.00133
LUADSPTBN1_S2165 →-0.406-0.821<.001<.00133
BRCANES_S1286 →-0.845-0.648.005<.00124
UCECXRCC5_S577 →+0.919+1.657<.001<.00133
HNSCCERS6 →-0.717-0.360<.001<.00124
PDACATP5MPL →+0.422+0.676.003<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration