Negative regulation of receptor recycling

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL308P, TUBBP1, and IFITM3P4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor recycling activity versus RN7SL308P in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RN7SL308P →	-0.461	-0.282	.002	.008	3	5
CCRCC	TUBBP1 →	+0.346	+0.722	.001	.001	3	4
BRCA	IFITM3P4 →	+1.394	+0.783	.001	<.001	2	5
BRCA	ARPC3P5 →	+0.658	+0.577	.001	.001	3	4
BRCA	FTH1P16 →	+1.502	+0.449	<.001	.009	3	4
GBM	ERMN →	+1.566	+0.556	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001920 vs RN7SL308P — PDAC

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