Negative regulation of receptor recycling

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF483, EEF2K, and GLB1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF483 grouped by Negative regulation of receptor recycling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF483 →	+0.605	+1.157	.002	<.001	3	4
KIDNEY	EEF2K →	-0.902	-1.360	.004	<.001	3	3
BREAST	GLB1L →	+0.908	+0.989	.001	.001	3	3
SOFT_TISSUE	CTSV →	+2.160	+1.536	.007	.004	2	4
CNS	BLMH →	+0.526	+0.786	.007	.005	3	3
CNS	PEX1 →	+0.681	+1.141	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF483 by Negative regulation of receptor recycling activity — CNS

Explore this box plot interactively →