Negative regulation of receptor recycling

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PANX1, SLC22A23, and ATP13A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor recycling activity versus PANX1 in LARGE_INTESTINE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PANX1 →	+1.315	+1.212	.001	.005	3	4
STOMACH	SLC22A23 →	-2.117	-0.495	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ATP13A3 →	+1.102	+0.418	<.001	<.001	3	3
LUNG_NSCLC_LUAD	FST →	+3.714	+0.441	<.001	.003	3	3
LUNG_NSCLC_LUAD	CENPX →	-1.516	-0.530	.005	<.001	3	3
LUNG_NSCLC_LUAD	ARHGAP23 →	+3.061	+0.381	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001920 vs PANX1 — LARGE_INTESTINE

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