Positive regulation of T cell mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell mediated cytotoxicity pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTX3L, PARP14, and STAT1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated cytotoxicity activity versus DTX3L in UCEC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DTX3L →	+0.487	+0.071	<.001	<.001	3	10
LSCC	PARP14 →	+0.373	+0.053	<.001	.001	3	10
UCEC	STAT1 →	+0.812	+0.078	<.001	<.001	3	9
OV	TAP1 →	+0.744	+0.043	<.001	.003	3	9
BRCA	TAP2 →	+0.752	+0.027	<.001	<.001	3	9
CCRCC	TAPBP →	+0.612	+0.053	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001916 vs DTX3L — UCEC

Explore this scatter interactively →