Positive regulation of T cell mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8-AS1, SLAMF7, and IFNG, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated cytotoxicity activity versus PSMB8-AS1 in LSCC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSMB8-AS1 →	+0.684	+0.310	<.001	<.001	3	10
BRCA	SLAMF7 →	+1.295	+0.178	<.001	.002	3	10
HNSC	IFNG →	+1.108	+0.225	<.001	<.001	3	9
BRCA	STAT1 →	+1.128	+0.208	<.001	<.001	3	9
COAD	NLRC5 →	+0.933	+0.162	<.001	.001	3	9
BRCA	GBP5 →	+1.502	+0.222	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001916 vs PSMB8-AS1 — LSCC

Explore this scatter interactively →