Negative regulation of T cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL17, CACNA1B, and MELK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CXCL17 grouped by Negative regulation of T cell mediated cytotoxicity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CXCL17 →	+0.058	+1.032	.002	<.001	3	4
LUNG_NSCLC_LUSC	CACNA1B →	-0.683	-1.429	<.001	<.001	3	4
LUNG_NSCLC_LUSC	MELK →	-0.848	-1.612	.002	.005	3	4
LUNG_NSCLC_LUSC	GTSE1 →	-0.890	-1.446	.003	.003	3	4
KIDNEY	NAV3 →	+1.085	+1.268	.002	<.001	3	4
BLOOD_Myeloma	PHKA2 →	-0.723	-2.062	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CXCL17 by Negative regulation of T cell mediated cytotoxicity activity — CNS

Explore this box plot interactively →