Negative regulation of T cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell mediated cytotoxicity pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REG4, OPN1MW, and UNG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, REG4 grouped by Negative regulation of T cell mediated cytotoxicity-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	REG4 →	-0.152	-0.148	.007	.006	3	4
BONE	OPN1MW →	+0.231	+1.993	.001	.004	3	4
SOFT_TISSUE	UNG →	-0.220	-1.073	.004	.009	3	3
BREAST	TCF23 →	+0.190	+1.163	.005	.004	2	4
LARGE_INTESTINE	MGAT3 →	-0.157	-1.630	.007	<.001	3	3
OESOPHAGUS	GINS4 →	+0.299	+0.170	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

REG4 by Negative regulation of T cell mediated cytotoxicity activity — OESOPHAGUS

Explore this box plot interactively →