Negative regulation of T cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM1, LIPH, and FERMT2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T cell mediated cytotoxicity activity versus CEACAM1 in LIVER (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CEACAM1 →	+3.725	+1.976	<.001	<.001	3	14
PANCREAS	LIPH →	+2.792	+1.790	<.001	<.001	3	11
STOMACH	FERMT2 →	-2.792	-1.547	<.001	<.001	3	10
STOMACH	CEACAM6 →	+5.469	+1.856	<.001	<.001	3	10
STOMACH	ST6GALNAC1 →	+2.288	+1.381	.007	.001	3	10
URINARY_TRACT	SLC44A3 →	+3.592	+1.419	<.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001915 vs CEACAM1 — LIVER

Explore this scatter interactively →