Regulation of T cell mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the Regulation of T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD7, HCP5, and BIN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated cytotoxicity activity versus CD7 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD7 →	+0.735	+0.160	.003	.001	3	9
BRCA	HCP5 →	+0.967	+0.147	<.001	<.001	3	9
GBM	BIN2 →	+0.999	+0.230	<.001	<.001	3	9
GBM	PTPRC →	+0.989	+0.194	<.001	<.001	3	9
LSCC	TLR8 →	+0.657	+0.243	<.001	<.001	3	8
HNSC	IFNG →	+0.925	+0.294	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001914 vs CD7 — BRCA

Explore this scatter interactively →