Regulation of T cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Regulation of T cell mediated cytotoxicity pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ESRRB, OTOL1, and MAGEA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ESRRB grouped by Regulation of T cell mediated cytotoxicity-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ESRRB →	-0.155	-0.155	.003	.006	3	5
LUNG_NSCLC_LUSC	OTOL1 →	+0.340	+0.168	<.001	.002	3	5
LUNG_NSCLC_LUSC	MAGEA1 →	-0.243	-0.227	<.001	<.001	3	5
BREAST	ZNF250 →	-0.397	-0.123	<.001	.001	3	5
LIVER	PXDNL →	-0.173	-0.173	.008	.005	3	4
SOFT_TISSUE	BAG1 →	+0.143	+0.232	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ESRRB by Regulation of T cell mediated cytotoxicity activity — SOFT_TISSUE

Explore this box plot interactively →