T cell mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the T cell mediated cytotoxicity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RENBP, SASH3, and STK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell mediated cytotoxicity activity versus RENBP in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RENBP →	+0.524	+0.080	<.001	<.001	3	10
CCRCC	SASH3 →	+0.490	+0.060	<.001	<.001	3	10
LSCC	STK10 →	+0.453	+0.061	<.001	<.001	3	10
BRCA	TAPBP →	+0.645	+0.030	<.001	<.001	3	10
GBM	CARD16 →	+0.853	+0.078	<.001	<.001	3	10
GBM	CYRIB →	+0.472	+0.111	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001913 vs RENBP — GBM

Explore this scatter interactively →