T cell mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD7, HCP5, and IL2RG, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell mediated cytotoxicity activity versus CD7 in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD7 →	+0.741	+0.206	<.001	<.001	3	9
OV	HCP5 →	+1.191	+0.252	<.001	<.001	3	9
OV	IL2RG →	+1.097	+0.254	.001	.001	3	9
OV	TIGIT →	+1.003	+0.269	<.001	<.001	3	8
OV	NLRC5 →	+1.175	+0.261	<.001	<.001	3	8
OV	GBP5 →	+1.769	+0.326	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001913 vs CD7 — OV

Explore this scatter interactively →