T cell mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the T cell mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPCN1, NOTCH2NLA, and EID2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell mediated cytotoxicity activity versus TPCN1 in LUNG_NSCLC_LUAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TPCN1 →	+1.286	+0.207	<.001	.009	3	6
LUNG_SCLC	NOTCH2NLA →	+1.748	+0.940	<.001	.002	3	6
BLOOD_Leukemia	EID2B →	-0.643	-0.193	.006	.006	3	6
SOFT_TISSUE	MILR1 →	+2.755	+0.410	.007	.005	3	5
BLOOD_Leukemia	INPP4B →	+1.291	+0.195	<.001	<.001	3	5
LUNG_NSCLC_LUAD	LRP5 →	+1.163	+0.211	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001913 vs TPCN1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →