Regulation of leukocyte mediated cytotoxicity

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIRC3, HLA-C, and CCN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte mediated cytotoxicity activity versus BIRC3 in BLOOD_Myeloma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	BIRC3 →	+4.076	+0.365	.002	.008	3	8
CNS	HLA-C →	+2.008	+0.273	.002	<.001	3	8
PANCREAS	CCN1 →	+2.549	+0.255	.001	<.001	3	8
SOFT_TISSUE	HLA-A →	+3.056	+0.291	.001	.001	3	7
STOMACH	RPL3 →	-0.839	-0.289	.003	.003	3	7
BONE	ACTN4 →	+1.774	+0.501	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001910 vs BIRC3 — BLOOD_Myeloma

Explore this scatter interactively →