Leukocyte mediated cytotoxicity

Across TCGA patient cohorts, RNA activity of the Leukocyte mediated cytotoxicity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, ITGAL, and BIN2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte mediated cytotoxicity activity versus ARHGAP9 in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP9 →	+0.970	+0.187	<.001	<.001	3	10
HNSC	ITGAL →	+0.939	+0.189	<.001	<.001	3	10
LSCC	BIN2 →	+0.844	+0.269	<.001	<.001	3	9
GBM	SIGLEC10 →	+0.949	+0.211	<.001	<.001	3	9
GBM	FCGR1B →	+0.636	+0.190	<.001	<.001	3	9
GBM	LCP2 →	+0.882	+0.206	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001909 vs ARHGAP9 — HNSC

Explore this scatter interactively →